Isomorphic Labs IsoDDE vs AlphaFold vs Insilico Medicine
A side-by-side look at scores, pricing and features — with RECATOOLS' ASEAN-aware verdict for each.
Isomorphic Labs IsoDDE
DeepMind's AI Drug Design Engine that doubles AlphaFold 3 accuracy in...
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AlphaFold
Google DeepMind's protein-structure prediction AI — the Nobel-winning...
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| RECATOOLS Score | 8.2 / 10 | 8.5 / 10 | 8.7 / 10 |
| Capability | — | ||
| Value for money | — | ||
| Ease of use | — | ||
| ASEAN readiness | — | ||
| API quality | — | ||
| Pricing | Enterprise | Free | Enterprise |
| Free tier | None — no free or academic tier publicly available | Free AlphaFold Server (non-commercial) plus the open AlphaFold Protein Structure Database; AF3 model code released for non-commercial use. | Chemistry42 cloud offers academic/startup access tiers; contact required |
| Paid from | Enterprise partnership only; deals structured around R&D milestones (not per-seat or API) | — | Enterprise licensing; upfront deals from $10M milestone to $115M (Lilly) |
| Has API | ✗ | ✗ | ✓ |
| Open source | ✗ | ✓ | ✗ |
| Free to use | ✗ | ✓ | ✗ |
| Users | Not publicly disclosed; access limited to pharma partnership cohort | 3M+ researchers | 13 of top 20 global pharma cos; 18.3% YoY subscription growth (2025) |
| Founded | 2021 | — | 2014 |
| Maker | Alphabet Inc. (via Google DeepMind spinoff) | Google DeepMind | Insilico Medicine (independent; HKEX: 3696) |
| Verdict | Isomorphic Labs IsoDDE represents a genuine scientific leap in AI-driven drug design — its 50% accuracy on the hardest protein-ligand prediction benchmark, outperformance of physics-based gold standards in binding affini... |
What this is for: Predicting the 3D structure of proteins and their complexes with DNA, RNA and small molecules, accelerating structural biology and drug discovery. Who this is for: Academic and non-commercial researche... |
Insilico Medicine holds a lead no other AI-native drug company currently matches: a molecule it designed from scratch has reached Phase III, with published peer-reviewed efficacy data behind it. The Pharma.AI stack — Pan... |
| Full review → | Full review → | Full review → |
Comparisons cover up to 4 tools. Scores are RECATOOLS editorial assessments; verify current pricing on each vendor's site.